The Metabolic Conversion of 9,11,13-Eleostearic Acid (18:3) to 9,11-Conjugated Linoleic Acid (18:2) in the Rat

Metabolic effects of conjugated linoleic acid

Fatty acids containing trans unsaturated double bonds occur in nature, but the most common dietary source are “man-treated” fats. Because of the possible link between trans-fatty acids consumption and human disease-mainly cardiovascular disease and cancer, the health effects of trans-FA have been studied for over the last fifty years. Trans fatty acids are unsaturated fatty acids with at least ...

Protective Effects of Linoleic Acid against the Cytotoxicity of Palmitic Fatty Acid in Rat Cardiomyocytes

Background & Aims: Lipotoxicity is the process through which accumulation of lipid intermadiates leads to cellular dysfunction. The worldwide prevalence of cardiovascular diseases has been increased dramatically due to lipotoxicity. According to the peformed studies, saturated and unsaturated fatty acids differ significantly in their contributions to lipotoxicity. It has been r...

Conversion of oleic acid to linoleic acid.

Reports from this laboratory have described the formation of palmitoleic and oleic acids from their saturated counterparts by enzyme systems of yeast (2, 3). For introducing a double bond into the 9,lO position of the aliphatic chain, the desaturating enzymes, acting on the coenzyme A derivatives of the fatty acids, require reduced triphosphopyridine nucleotide, and molecular oxygen as hydrogen...

Slow absorption of conjugated linoleic acid in rat intestines, and similar absorption rates of 9c,11t-conjugated linoleic acid and 10t,12c-conjugated linoleic acid.

We have previously shown that the 9c,11t-conjugated linoleic acid (CLA) concentration was always significantly higher than the 10t,12c-CLA concentration following the administration of these compounds to mice and rats, and considered that structural differences between the conjugated double bonds in these isomers affected absorption in the small intestine. This study investigates the absorption...

Conjugated Linoleic Acid Targets